This archeological part of the museum is pre-eminent and appreciated in Romania and abroad. It is very important the exhibition of metal age (2800-1400 B.C.) and late iron age (350 B.C.-100 A.D.), which has been presented in Bucharest, Baia Mare, Cluj, Milan, Hochdorf.

The Károlyi castle is the only museum in Satu Mare county which has a permanent nature exhibition, made of 25,000 pieces presenting the county's flora and fauna. There are six rooms with geological presentations presenting the county's geological formation, its fossils and the present day flora and fauna.